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Reserve concomitant prescribing of these medications in sufferers for whom other treatment selections are insufficient. Restrict dosages and durations for the minimum amount required. Observe closely for indications of respiratory depression and sedation.

pentobarbital will lessen the extent or influence of rolapitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Lengthy-time period coadministration of robust CYP3A4 inducers with rolapitant may perhaps considerably lower rolapitant efficacy.

pentobarbital decreases results of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of CYP3A4 inducers may decrease sufentanil levels and efficacy, possibly precipitating withdrawal syndrome in patients who have designed Bodily dependence to sufentanil. Discontinuation of concomitantly utilized CYP3A4 inducers might increase sufentanil plasma concentration.

pentobarbital will minimize the level or influence of ibuprofen by affecting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Significance Unfamiliar.

pentobarbital will lower the extent or result of colchicine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.

pentobarbital will decrease the level or result of quinine by influencing hepatic/intestinal enzyme here CYP3A4 metabolism. Slight/Importance Unknown.

pentobarbital improves toxicity of buprenorphine, long-performing injection by pharmacodynamic synergism. Modify Therapy/Keep track of Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants will increase danger of adverse reactions which includes overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is chosen typically.

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pentobarbital will lessen the extent or impact of maraviroc by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will decrease the level or influence of lapatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will lessen the extent or outcome of galantamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.

pentobarbital will minimize the extent or influence of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

fentanyl transmucosal and pentobarbital each maximize sedation. Prevent or Use Alternate Drug. Restrict use to sufferers for whom option treatment method choices are insufficient

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